Sejong Open Cluster Survey (SOS). 0. Target Selection and Data Analysis

Star clusters are superb astrophysical laboratories containing cospatial and coeval samples of stars with similar chemical composition. We have initiated the Sejong Open cluster Survey (SOS) - a project dedicated to providing homogeneous photometry of a large number of open clusters in the SAAO Johnson-Cousins' $UBVI$ system. To achieve our main goal, we have paid much attention to the observation of standard stars in order to reproduce the SAAO standard system. Many of our targets are relatively small, sparse clusters that escaped previous observations. As clusters are considered building blocks of the Galactic disk, their physical properties such as the initial mass function, the pattern of mass segregation, etc. give valuable information on the formation and evolution of the Galactic disk. The spatial distribution of young open clusters will be used to revise the local spiral arm structure of the Galaxy. In addition, the homogeneous data can also be used to test stellar evolutionary theory, especially concerning rare massive stars. In this paper we present the target selection criteria, the observational strategy for accurate photometry, and the adopted calibrations for data analysis such as color-color relations, zero-age main sequence relations, Sp - Mv relations, Sp - Teff relations, Sp - color relations, and Teff - BC relations. Finally we provide some data analysis such as the determination of the reddening law, the membership selection criteria, and distance determination.Comment: 21 pages, 16 figures, accepted for publication in J. of Korean Astronomical Society (JKAS

Tonicity response element binding protein associated with neuronal cell death in the experimental diabetic retinopathy

AIM: To study the contribution of tonicity response element binding protein (TonEBP) in retinal ganglion cell (RGC) death of diabetic retinopathy (DR). METHODS: Diabetes was induced in C57BL/6 mice by five consecutive intraperitoneal injections of 55 mg/kg streptozotocin (STZ). Control mice received vehicle (phosphate -buffered saline). All mice were killed 2mo after injections, and the extent of cell death and the protein expression levels of TonEBP and aldose reductase (AR) were examined. RESULTS: The TonEBP and AR protein levels and the death of RGC were significantly increased in the retinas of diabetic mice compared with controls 2mo after the induction of diabetes. Terminal deoxynucleotidyl transferase (TdT) -mediated dUTP nick end labeling (TUNEL) -positive signals co -localized with TonEBP immunoreactive RGC. These changes were increased in the diabetic retinas compared with controls. CONCLUSION: The present data show that AR and TonEBP are upregulated in the DR and TonEBP may contribute to apoptosis of RGC in the DR.close2

An Optical and Infrared Photometric Study of the Young Open Cluster IC 1805 in the Giant H II Region W4

We present deep wide-field optical CCD photometry and mid-infrared Spitzer/IRAC and MIPS 24micron data for about 100,000 stars in the young open cluster IC 1805. The members of IC 1805 were selected from their location in the various color-color and color-magnitude diagrams, and the presence of Halpha emission, mid-infrared excess emission, and X-ray emission. The reddening law toward IC 1805 is nearly normal (R_V = 3.05+/-0.06). However, the distance modulus of the cluster is estimated to be 11.9+/-0.2 mag (d = 2.4+/-0.2 kpc) from the reddening-free color-magnitude diagrams, which is larger than the distance to the nearby massive star-forming region W3(OH) measured from the radio VLBA astrometry. We also determined the age of IC 1805 (tau_MSTO = 3.5 Myr). In addition, we critically compared the age and mass scale from two pre-main-sequence evolution models. The initial mass function with a Salpeter-type slope of Gamma = -1.3+/-0.2 was obtained and the total mass of IC 1805 was estimated to be about 2700+/-200 M_sun. Finally, we found our distance determination to be statistically consistent with the Tycho-Gaia Astrometric Solution Data Release 1, within the errors. The proper motion of the B-type stars shows an elongated distribution along the Galactic plane, which could be explained by some of the B-type stars being formed in small clouds dispersed by previous episodes of star formation or supernova explosions.Comment: 45 pages, 32 figures, 9 tables, accepted for publication in ApJ

Development of Moving Particle Simulation Method for Multiliquid-Layer Sloshing

The mixed oil and gas including water and sand are extracted from well to offshore structure. This mixed fluid must be separated for subsequent processes by using wash tanks or separators. To design such a system, a proper numerical-prediction tool for multiphase fluids is required. In this regard, a new moving particle simulation (MPS) method is developed to simulate multiliquid-layer sloshing problems. The new MPS method for multifluid system includes extra search methods for interface particles, boundary conditions for interfaces, buoyancy-correction model, and surface-tension model for interface particles. The new particle interaction models are verified through comparisons with published numerical and experimental data. In particular, the multiliquid MPS method is verified against Molin et al’s (2012) experiment with three liquid layers. In case of excitation frequency close to one of the internal-layer resonances, the internal interface motions can be much greater than top free-surface motions. The verified multiliquid MPS program is subsequently used for more nonlinear cases including multichromatic multimodal motions with larger amplitudes, from which various nonlinear features, such as internal breaking and more particle detachment, can be observed. For the nonlinear case, the differences between with and without buoyancy-correction and surface-tension models are also demonstrated

Reddening, distance, and stellar content of the young open cluster Westerlund 2

We present deep UBVIC photometric data of the young open cluster Westerlund 2. An abnormal reddening law of RV, cl = 4.14 ± 0.08 was found for the highly reddened early-type members (E(B−V)≧1.45E(B−V)≧1.45), whereas a fairly normal reddening law of RV, fg = 3.33 ± 0.03 was confirmed for the foreground early-type stars (E(B − V)fg < 1.05). The distance modulus was determined from zero-age main-sequence fitting to the reddening-corrected colour–magnitude diagram of the early-type members to be V0 − MV = 13.9 ± 0.14 (random error) +0.4−0.1−0.1+0.4 (the upper limit of systematic error) mag (d=6.0±0.4+1.2−0.3d=6.0±0.4−0.3+1.2 kpc). To obtain the initial mass function, pre-main-sequence (PMS) stars were selected by identifying the optical counterparts of Chandra X-ray sources and mid-infrared emission stars from the Spitzer GLIMPSE (Galactic Legacy Infrared Mid-Plane Survey Extraordinaire) source catalogue. The initial mass function shows a shallow slope of Γ = −1.1 ± 0.1 down to log m = 0.7. The total mass of Westerlund 2 is estimated to be at least 7 400 M⊙. The age of Westerlund 2 from the main-sequence turn-on and PMS stars is estimated to be ≲ 1.5 Myr. We confirmed the existence of a clump of PMS stars located ∼1 arcmin north of the core of Westerlund 2, but we could not find any clear evidence for an age difference between the core and the northern clump

Does the Kyphotic Change Decrease the Risk of Fall?

ObjectivesFalls are a major problem in the elderly. Age-related degeneration of the human balance system increases the risk of falls. Kyphosis is a common condition of curvature of the upper spine in the elderly and its development occurs through degenerative change. However, relatively little is known about the effect of kyphotic changes on balance in the elderly. The aim of this study is to investigate the influence of kyphosis on the balance strategy through use of the motor control test (MCT) in computerized dynamic posturography.MethodsFifty healthy subjects who were not affected by other medical disorders that could affect gait or balance were enrolled in the study. By simulation of kyphotic condition through change of the angles of the line connecting the shoulder to the hip and the ankle axis by approximately 30°, the latency and amplitude of the MCT were measured in upright and kyphotic condition.ResultsIn the kyphotic condition, latency was shortened in backward movement. In forward movement, latency was shortened only in large stimulation. The amplitude in forward movement was decreased in kyphotic condition. However, the change of amplitude was not significant in large intensity backward movement in the same condition.ConclusionKyphotic condition decreases the latency of MCT, especially in backward movement. These findings imply that kyphotic condition may serve as a protective factor against falls

Reddening, Distance, and Stellar Content of the Young Open Cluster Westerlund 2

We present deep $UBVI_C$ photometric data of the young open cluster Westerlund 2. An abnormal reddening law of $R_{V,cl}=4.14\pm0.08$ was found for the highly reddened early-type members ($E(B-V)\geq 1.45$), whereas a fairly normal reddening law of $R_{V,fg}=3.33\pm0.03$ was confirmed for the foreground early-type stars ($E(B-V)_{fg}<1.05$). The distance modulus was determined from zero-age main-sequence (ZAMS) fitting to the reddening-corrected colour-magnitude diagram of the early-type members to be $V_0-M_V=13.9\pm0.14$ (random error) $_{-0.1}^{+0.4}$ (the upper limit of systematic error) mag ($d = 6.0 \pm 0.4 _{-0.3}^{+1.2}$ kpc). To obtain the initial mass function, pre-main-sequence (PMS) stars were selected by identifying the optical counterparts of Chandra X-ray sources and mid-infrared emission stars from the Spitzer GLIMPSE source catalog. The initial mass function shows a shallow slope of $\Gamma=-1.1 \pm 0.1$ down to $\log m = 0.7$. The total mass of Westerlund 2 is estimated to be at least 7,400 $M_{\odot}$. The age of Westerlund 2 from the main-sequence turn-on and PMS stars is estimated to be $\lesssim$ 1.5 Myr. We confirmed the existence of a clump of PMS stars located $\sim1$ arcmin north of the core of Westerlund 2, but we could not find any clear evidence for an age difference between the core and the northern clump.Comment: 25 pages, 22 figures, 6 tables, accepted for publication in MNRA

Cyr61 Expression is associated with prognosis in patients with colorectal cancer

BACKGROUND: Cysteine-rich 61 (Cyr61), a member of the CCN protein family, possesses diverse functionality in cellular processes such as adhesion, migration, proliferation, and survival. Cyr61 can also function as an oncogene or a tumour suppressor, depending on the origin of the cancer. Only a few studies have reported Cyr61 expression in colorectal cancer. In this study, we assessed the Cyr61 expression in 251 colorectal cancers with clinical follow up. METHODS: We examined Cyr61 expression in 6 colorectal cancer cell lines (HT29, Colo205, Lovo, HCT116, SW480, SW620) and 20 sets of paired normal and colorectal cancer tissues by western blot. To validate the association of Cyr61 expression with clinicopathological parameters, we assessed Cyr61 expression using tissue microarray analysis of primary colorectal cancer by immunohistochemical analysis. RESULTS: We verified that all of the cancer cell lines expressed Cyr61; 2 cell lines (HT29 and Colo205) demonstrated Cyr61 expression to a slight extent, while 4 cell lines (Lovo, HCT116, SW480, SW620) demonstrated greater Cyr61 expression than HT29 and Colo205 cell lines. Among the 20 cases of paired normal and tumour tissues, greater Cyr61 expression was observed in 16 (80%) tumour tissues than in normal tissues. Furthermore, 157 out of 251 cases (62.5%) of colorectal cancer examined in this study displayed strong Cyr61 expression. Cyr61 expression was found to be associated with pN (p = 0.018). Moreover, Cyr61 expression was associated with statistically significant cancer-specific mortality (p = 0.029). The duration of survival was significantly lesser in patients with Cyr61 high expression than in patients with Cyr61 low expression (p = 0.001). These results suggest that Cyr61 expression plays several important roles in carcinogenesis and may also be a good prognostic marker for colorectal cancer. CONCLUSIONS: Our data confirmed that Cyr61 was expressed in colorectal cancers and the expression was correlated with worse prognosis of colorectal cancers